Modeling Dilated Cardiomyopathies in Drosophila
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چکیده
منابع مشابه
Dilated cardiomyopathies in dogs
Dilated cardiomyopathy (DCM) is primary disease of the muscle of the heart, characterized by a progressive decline in the contractility of the ventricles, dilation of all the cardiac chambers, leading to congestive heart failure (CHF), arrhythmias, and death. Histopathology of the cardiac muscle (myocardium) reveals necrosis of cardiac cells, scar tissue (fibrosis), and sometimes replacement of...
متن کاملProfiles in Dilated (Congestive) and Hypertrophic Cardiomyopathies
Cardiomyopathies are primary disorders of heart muscle. Although the term is sometimes restricted to refer to cardiac muscle disorders of unknown etiology, most cardiologists include disorders of both unknown and known etiology. For example, the cardiac muscle disorder associated with long-standing ingestion of excessive quantities of ethanol is generally termed and the disorder resulting from ...
متن کاملMolecular Signature of Nitroso–Redox Balance in Idiopathic Dilated Cardiomyopathies
BACKGROUND Idiopathic dilated cardiomyopathy is one of the most common types of cardiomyopathy. It has been proposed that an increase in oxidative stress in heart failure leads to a decrease in nitric oxide signaling, leading to impaired nitroso-redox signaling. To test this hypothesis, we investigated the occurrence of protein S-nitrosylation (SNO) and oxidation in biopsies from explanted dila...
متن کاملHearing Profile in Patients with Dilated and Hypertrophic Cardiomyopathies
INTRODUCTION Cardiomyopathy may cause disruptions in the micro-vascular system of the stria vascularis in the cochlea, and, subsequently, may result in cochlear degeneration. Degeneration in the stria vascularis affects the physical and chemical processes in the organ of Corti, thereby causing a possible hearing impairment. The objective of this study was to assess the hearing profiles of patie...
متن کاملShared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies.
Background Peripartum cardiomyopathy shares some clinical features with idiopathic dilated cardiomyopathy, a disorder caused by mutations in more than 40 genes, including TTN, which encodes the sarcomere protein titin. Methods In 172 women with peripartum cardiomyopathy, we sequenced 43 genes with variants that have been associated with dilated cardiomyopathy. We compared the prevalence of diff...
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ژورنال
عنوان ژورنال: Trends in Cardiovascular Medicine
سال: 2012
ISSN: 1050-1738
DOI: 10.1016/j.tcm.2012.06.012